Eagles at 49ers, 5:15 p.m. FOX
Giants at Washington, 7:15 p.m. FOX
Seahawks at Raiders, 10:15 p.m. NBC
Important note about NFL Week 10 and Sunday Night Football
When the Giants play the Redskins, Giants quarterback Eli Manning will match up with Redskins QB Alex Smith for the third time. Smith and Manning have one win each in those matchups. Smith has attempted 231 passes in the two games with a 4-2 touchdown to interception ratio and an average of 296 yards per game. Manning has thrown 131 passes in the two games and has a passer rating of 81.8 with six touchdowns and two interceptions.
When the Giants play the Raiders, Raiders quarterback Derek Carr will be looking to snap a two-game losing streak. Carr and the Raiders will try to right the ship against a Giants defense that has allowed 300-yard passing games to Baker Mayfield, Philip Rivers and Patrick Mahomes over the last three games.
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The biggest matchups of the day
Can Andrew Luck take down the Steelers?
There are two massive, top-10 matchup's on this week's NFL schedule with the Colts traveling to Pittsburgh and the Titans hosting the Texans.
The Steelers are coming off a win over the Panthers but still sitting on their heels with the Ravens, Bengals and Saints. The Steelers haven't won a game without Ben Roethlisberger since 2013. The Colts are in last place in the AFC South at 3-5 but they are 3-1 in their last four games. Andrew Luck and the Colts have played better in recent weeks. Luck has thrown four touchdowns and just one interception in the last three games.
In case you missed it, Colts WR T.Y. Hilton and Steelers RB James Conner have a rivalry dating back to college. Hilton is motivated this week against Conner after missing two straight games with a hamstring injury. Colts rookie LB Darius Leonard was named AFC Defensive Player of the Week after making eight tackles and recovering a fumble against the Jaguars.
When will the Texans finally win a game?
The Texans are 0-3 against teams with winning records this season, with losses to the Cowboys, Texans and Colts. After Week 1, the Texans have won nine straight games against teams with losing records. The Texans were nearly the second team to the Patriots' 18-0 record in the 2018 season but lost 27-20.
In Week 5, the Texans lost against the Bills in Week 4 and against the Patriots in Week 3. After losing to the Colts, the Texans are suddenly looking up in the AFC South with a record of 3-5. The Texans have had an ugly 0-3 start, but if they can win their next two games, they will have a shot to knock off the first-place Saints.
The Titans will host the Texans in Nashville this Sunday. This game will be a crucial game for the Texans to avoid falling behind in the division. After the game, the Texans face the Steelers in Pittsburgh.
Related: Chargers vs. Chiefs is a game-changer in the AFC West
The Texans are giving up the most points per game at 29.8. The Titans are giving up the fewest points per game at 18.6. The Colts and Patriots are second and third, respectively.
When will the Dolphins finally have a win?
The Dolphins are finally 4-3 after beating the Patriots and Jets last weekend. After starting the season 1-4, they now have a chance to keep pace in the AFC East. The Dolphins will try to keep it going against the Bears in Miami.
The Bears are 5-3 after beating the Vikings 24-17. Chicago beat the Lions 31-23 last weekend.
Did the Cowboys finally fix their defense?
The Cowboys have won three straight games after starting the season 0-2. In the three wins, Dallas allowed 25, 14 and 16 points per game. But they surrendered 20 to the Jaguars, 15 to the Falcons and 30 to the Saints, with 35 coming in the overtime loss against the Saints.
The Saints’ point total was their most since a 45-35 win over the Cowboys in the playoffs. It marked the most points allowed by the Cowboys this season.
What did the Steelers do to get their first win?
It was a 34-13 win against the Panthers last week. The win was James Conner's first game without a touchdown since September 8, 2017. Conner ran for 111 yards and a touchdown. The Steelers forced three turnovers against the Panthers, after having just three all season coming into the game.
The Panthers are coming off a 21-17 win against the Patriots. New England has won seven straight against the Panthers. The two teams met in Week 4 at Heinz Field.
Did the Ravens finally solve the Browns offense?
The Browns' first win of the season was a 36-21 home victory over the Bengals. Since the beginning of the 2014 season, the Browns are 8-59 against the Ravens. Cleveland defeated the Ravens 26-24 in overtime to open the season.
Derek Anderson will start at quarterback for the Browns with starter Baker Mayfield (ankle) injured.
No team in the NFL this season has committed more turnovers than the Browns (11).
The Ravens are coming off a 24-21 win against the Falcons and have won three straight games. The Ravens' next three games are against the Bengals, Raiders and Falcons.
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